Studying the API Distribution of Controlled Release Formulations Produced via Continuous Twin-Screw Wet Granulation: Influence of Matrix Former, Filler and Process Parameters

Studying the API Distribution of Controlled Release Formulations Produced via Continuous Twin-Screw Wet Granulation: Influence of Matrix Former, Filler and Process Parameters

Hydroxypropyl methylcellulose (HPMC) is a preferred hydrophilic matrix former for controlled release formulations produced through continuous twin-screw wet granulation. However, a non-homogeneous API distribution over sieve fractions with underdosing in the fines fraction (<150 µm) was previousl...

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Bibliographic Details
Main Authors: Phaedra Denduyver, Chris Vervaet, Valérie Vanhoorne
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Pharmaceutics
Subjects:
continuous manufacturing
twin-screw granulation
wet granulation
controlled release
hydroxypropyl methylcellulose
process variables
Online Access:https://www.mdpi.com/1999-4923/16/3/341

Internet

https://www.mdpi.com/1999-4923/16/3/341

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