Targeting arginase-1 exerts antitumor effects in multiple myeloma and mitigates bortezomib-induced cardiotoxicity

Targeting arginase-1 exerts antitumor effects in multiple myeloma and mitigates bortezomib-induced cardiotoxicity

Abstract Multiple myeloma (MM) remains an incurable malignancy of plasma cells despite constantly evolving therapeutic approaches including various types of immunotherapy. Increased arginase activity has been associated with potent suppression of T-cell immune responses in different types of cancer....

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Bibliographic Details
Main Authors: Kavita Ramji, Tomasz M. Grzywa, Anna Sosnowska, Aleksandra Paterek, Marta Okninska, Zofia Pilch, Joanna Barankiewicz, Filip Garbicz, Katarzyna Borg, Urszula Bany-Laszewicz, Abdesamad Zerrouqi, Beata Pyrzynska, Anna Rodziewicz-Lurzynska, Diana Papiernik, Piotr Sklepkiewicz, Hanna Kedzierska, Adam Staruch, Radoslaw Sadowski, Olga Ciepiela, Ewa Lech-Maranda, Przemyslaw Juszczynski, Urszula Mackiewicz, Michal Maczewski, Dominika Nowis, Jakub Golab
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-24137-1

Internet

https://doi.org/10.1038/s41598-022-24137-1

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