Comparison of Liquid Chromatography–Tandem Mass Spectrometry and Sandwich ELISA for Determination of Keratan Sulfate in Plasma and Urine

Background and Aim Mucopolysaccharidosis IVA (MPS IVA) leads to skeletal dysplasia through excessive storage of chondroitin-6-sulfate and keratan sulfate (KS). KS is synthesized mainly in cartilage and released into circulation, making it a critical|biomarker for MPS IVA to evaluate clinical course...

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Bibliographic Details
Main Authors: Jonathan P. Hintze, Shunji Tomatsu, Tadashi Fujii, Adriana M. Montaño, Seiji Yamaguchi, Yasuyuki Suzuki, Masaru Fukushi, Takeshi Ishimaru, Tadao Orii
Format: Article
Language:English
Published: SAGE Publishing 2011-01-01
Series:Biomarker Insights
Online Access:https://doi.org/10.4137/BMI.S7451