Structure–Activity Relationship of 5-mer Catalytides, GSGYR and RYGSG

Structure–Activity Relationship of 5-mer Catalytides, GSGYR and RYGSG

We recently discovered JAL-TA9 (YKGSGFRMI), a short hydrolytic peptide that we termed a Catalytide. The catalytic center of JAL-TA9 was modeled using MM2 and MMFF94 parameters and identified as GSGFR. Additionally, a structure–activity relationship study showed that GSGYR cleaved Aβ11-29. Here, we d...

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Bibliographic Details
Main Authors: Rina Nakamura, Toshifumi Akizawa, Motomi Konishi
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Biomolecules
Subjects:
Catalytide
in silico
Alzheimer’s disease
amyloid-β
hydrolytic peptide
structure–activity relationship
Online Access:https://www.mdpi.com/2218-273X/12/12/1766

Internet

https://www.mdpi.com/2218-273X/12/12/1766

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