Hypervirulent group A Streptococcus emergence in an acaspular background is associated with marked remodeling of the bacterial cell surface.

Hypervirulent group A Streptococcus emergence in an acaspular background is associated with marked remodeling of the bacterial cell surface.

Inactivating mutations in the control of virulence two-component regulatory system (covRS) often account for the hypervirulent phenotype in severe, invasive group A streptococcal (GAS) infections. As CovR represses production of the anti-phagocytic hyaluronic acid capsule, high level capsule product...

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Bibliographic Details
Main Authors: Jessica Galloway-Peña, Sruti DebRoy, Chelcy Brumlow, Xiqi Li, Truc T Tran, Nicola Horstmann, Hui Yao, Ken Chen, Fang Wang, Bih-Fang Pan, David H Hawke, Erika J Thompson, Cesar A Arias, Vance G Fowler, Micah M Bhatti, Awdhesh Kalia, Anthony R Flores, Samuel A Shelburne
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0207897

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https://doi.org/10.1371/journal.pone.0207897

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