Anti-TIM3 chimeric antigen receptor-natural killer cells preferentially target primitive acute myeloid leukemia cells with minimal fratricide and exhaustion

Anti-TIM3 chimeric antigen receptor-natural killer cells preferentially target primitive acute myeloid leukemia cells with minimal fratricide and exhaustion

Abstract Acute myeloid leukemia (AML) is an aggressive and genetically heterogeneous disease with poor clinical outcomes. Refractory AML is common, and relapse remains a major challenge, attributable to the presence of therapy-resistant leukemic stem cells (LSCs), which possess self-renewal and repo...

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Bibliographic Details
Main Authors: Phatchanat Klaihmon, Parinya Samart, Yon Rojanasakul, Surapol Issaragrisil, Sudjit Luanpitpong
Format: Article
Language:English
Published: BMC 2024-07-01
Series:Experimental Hematology & Oncology
Subjects:
Acute myeloid leukemia
Immunotherapy
Chimeric antigen receptor
TIM3
Natural killer cell
Exhaustion
Online Access:https://doi.org/10.1186/s40164-024-00534-2

Internet

https://doi.org/10.1186/s40164-024-00534-2

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