COUP-TFII regulates early bipotential gonad signaling and commitment to ovarian progenitors

COUP-TFII regulates early bipotential gonad signaling and commitment to ovarian progenitors

Abstract Background The absence of expression of the Y-chromosome linked testis-determining gene SRY in early supporting gonadal cells (ESGC) leads bipotential gonads into ovarian development. However, genetic variants in NR2F2, encoding three isoforms of the transcription factor COUP-TFII, represen...

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Bibliographic Details
Main Authors: Lucas G. A. Ferreira, Marina M. L. Kizys, Gabriel A. C. Gama, Svenja Pachernegg, Gorjana Robevska, Andrew H. Sinclair, Katie L. Ayers, Magnus R. Dias-da-Silva
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Cell & Bioscience
Subjects:
46,XX DSD
Bipotential gonad
COUP-TFII
Sex development
Supporting gonadal cells
Online Access:https://doi.org/10.1186/s13578-023-01182-5

Internet

https://doi.org/10.1186/s13578-023-01182-5

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