Stylopine: A potential natural metabolite to block vascular endothelial growth factor receptor 2 (VEGFR2) in osteosarcoma therapy

Stylopine: A potential natural metabolite to block vascular endothelial growth factor receptor 2 (VEGFR2) in osteosarcoma therapy

Vascular endothelial growth factor (VEGF) signals cell survival, cell migration, osteogenesis, cell proliferation, angiogenesis, and vascular permeability by binding to VEGF receptor 2 (VEGFR-2). Osteosarcoma is the most common primary bone cancer, majorly affects young adults. Activation of VEGFR-2...

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Bibliographic Details
Main Authors: Naveen Kumar Velayutham, Tamilanban Thamaraikani, Shadma Wahab, Mohammad Khalid, Gobinath Ramachawolran, Shahabe Saquib Abullais, Ling Shing Wong, Mahendran Sekar, Siew Hua Gan, Angel Jemima Ebenezer, Mrinalini Ravikumar, Vetriselvan Subramaniyan, Nur Najihah Izzati Mat Rani, Yuan Seng Wu, Srikanth Jeyabalan
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Pharmacology
Subjects:
benzylisoquinoline alkaloids
stylopine
MG-63
osteosarcoma
VEGFR2
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1150270/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1150270/full

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