Brain-targeted delivery of neuroprotective survival gene minimizing hematopoietic cell contamination: implications for Parkinson’s disease treatment

Brain-targeted delivery of neuroprotective survival gene minimizing hematopoietic cell contamination: implications for Parkinson’s disease treatment

Abstract Background Neurodegenerative diseases, including Parkinson's disease, Amyotropic Lateral Sclerosis (ALS) and Alzheimer's disease, present significant challenges for therapeutic development due to drug delivery restrictions and toxicity concerns. Prevailing strategies often employ...

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Bibliographic Details
Main Authors: Min Hak Lee, Sukyeong Kang, Ki-Hwan Um, Seok Won Lee, Hyorin Hwang, Kyunghwa Baek, Jin Woo Choi
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Journal of Translational Medicine
Subjects:
AIMP2 splicing variants
DX2
miRNA
Parkinson’s disease
Adeno-associated virus
Gene therapy
Online Access:https://doi.org/10.1186/s12967-023-04816-x

Internet

https://doi.org/10.1186/s12967-023-04816-x

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