Modeling Therapy-Driven Evolution of Glioblastoma with Patient-Derived Xenografts

Modeling Therapy-Driven Evolution of Glioblastoma with Patient-Derived Xenografts

Adult-type diffusely infiltrating gliomas, of which glioblastoma is the most common and aggressive, almost always recur after treatment and are fatal. Improved understanding of therapy-driven tumor evolution and acquired therapy resistance in gliomas is essential for improving patient outcomes, yet...

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Bibliographic Details
Main Authors: Matthew McCord, Elizabeth Bartom, Kirsten Burdett, Aneta Baran, Frank D. Eckerdt, Irina V. Balyasnikova, Kathleen McCortney, Thomas Sears, Shi-Yuan Cheng, Jann N. Sarkaria, Roger Stupp, Amy B. Heimberger, Atique Ahmed, Charles David James, Craig Horbinski
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Cancers
Subjects:
CNS cancers
gliomas
glioblastomas
tumor evolution
DNA damage and repair
chemotherapy
Online Access:https://www.mdpi.com/2072-6694/14/22/5494

Internet

https://www.mdpi.com/2072-6694/14/22/5494

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