Non-heme iron overload impairs monocyte to macrophage differentiation via mitochondrial oxidative stress

Non-heme iron overload impairs monocyte to macrophage differentiation via mitochondrial oxidative stress

Iron is a key element for systemic oxygen delivery and cellular energy metabolism. Thus regulation of systemic and local iron metabolism is key for maintaining energy homeostasis. Significant changes in iron levels due to malnutrition or hemorrhage, have been associated with several diseases such as...

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Bibliographic Details
Main Authors: Yue Cui, Saray Gutierrez, Sheller Ariai, Lisa Öberg, Kristofer Thörn, Ulf Gehrmann, Suzanne M. Cloonan, Thomas Naessens, Henric Olsson
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
iron
differentiation
macrophage
mitochondria
heme
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.998059/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.998059/full

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