Inclusion complexes and self-assembled cyclodextrin aggregates for increasing the solubility of benzimidazoles

Inclusion complexes and self-assembled cyclodextrin aggregates for increasing the solubility of benzimidazoles

Albendazole and fenbendazole are imidazole derivatives that exhibit broad spectrum activity against parasites, but the low solubility of these drugs considerably reduces their effectiveness. Complexation of albendazole and fenbendazole with cyclodextrins (β-cyclodextrin and hydroxypropyl-β-cyclodext...

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Bibliographic Details
Main Authors: Leticia Norma Carpentieri Rodrigues, Anna Carollina Moraes Tavares, Beatriz Tavares Ferreira, Adriana Karla Cardoso Amorim Reis, Luciana Morita Katiki
Format: Article
Language:English
Published: Universidade de São Paulo 2019-11-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Cyclodextrins/pharmacokinetics
Benzimidazoles/administration & dosage
Inclusion complexes
Cyclodextrin aggregates
Drug liberation/drug effects
Antiparasitic agents/analysis
Albendazole/analysis
Fenbendazole/analysis
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100551&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100551&tlng=en

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