Study of Hypoglycemic Activity of Novel 9-N-alkyltetrahydroberberine Derivatives

Study of Hypoglycemic Activity of Novel 9-N-alkyltetrahydroberberine Derivatives

Novel 9-N-alkyltetrahydroberberine derivatives were synthesized, among which, based on the results of OGTT, one compound containing the longest aliphatic substituent was selected for study in mice C57BL/6<sup>Ay</sup>, which demonstrate obesity, impaired glucose tolerance, and concomitan...

Full description

Bibliographic Details
Main Authors: Mikhail V. Khvostov, Elizaveta D. Gladkova, Sergey A. Borisov, Marina S. Fedotova, Nataliya A. Zhukova, Mariya K. Marenina, Yuliya V. Meshkova, Olga A. Luzina, Tatiana G. Tolstikova, Nariman F. Salakhutdinov
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
berberine derivatives
metabolic syndrome
hypoglycemic activity
OGTT
agouti yellow mice
Online Access:https://www.mdpi.com/1422-0067/23/22/14186

Internet

https://www.mdpi.com/1422-0067/23/22/14186

Similar Items