SpyMask enables combinatorial assembly of bispecific binders
Abstract Bispecific antibodies are a successful and expanding therapeutic class. Standard approaches to generate bispecifics are complicated by the need for disulfide reduction/oxidation or specialized formats. Here we present SpyMask, a modular approach to bispecifics using SpyTag/SpyCatcher sponta...
| Main Authors: | , , |
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| 格式: | Article |
| 語言: | English |
| 出版: |
Nature Portfolio
2024-03-01
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| 叢編: | Nature Communications |
| 在線閱讀: | https://doi.org/10.1038/s41467-024-46599-9 |