Optimizations of lipid II synthesis: an essential glycolipid precursor in bacterial cell wall synthesis and a validated antibiotic target

Optimizations of lipid II synthesis: an essential glycolipid precursor in bacterial cell wall synthesis and a validated antibiotic target

Lipid II is an essential glycolipid found in bacteria. Accessing this valuable cell wall precursor is important both for studying cell wall synthesis and for studying/identifying novel antimicrobial compounds. Herein, we describe optimizations to the modular chemical synthesis of lipid II and unnatu...

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Bibliographic Details
Main Authors: Milandip Karak, Cian R. Cloonan, Brad R. Baker, Rachel V. K. Cochrane, Stephen A. Cochrane
Format: Article
Language:English
Published: Beilstein-Institut 2024-02-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
chemical glycosylation
lipid ii
peptidoglycan
polyprenyls
total synthesis
Online Access:https://doi.org/10.3762/bjoc.20.22

Internet

https://doi.org/10.3762/bjoc.20.22

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