3D Chromatin Architecture Re-Wiring at the <i>CDH3/CDH1</i> Loci Contributes to E-Cadherin to P-Cadherin Expression Switch in Gastric Cancer

3D Chromatin Architecture Re-Wiring at the <i>CDH3/CDH1</i> Loci Contributes to E-Cadherin to P-Cadherin Expression Switch in Gastric Cancer

Cadherins are cell–cell adhesion molecules, fundamental for cell architecture and polarity. E-cadherin to P-cadherin switch can rescue adherens junctions in epithelial tumours. Herein, we disclose a mechanism for E-cadherin to P-cadherin switch in gastric cancers. <i>CDH1</i> and <i&g...

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Bibliographic Details
Main Authors: Celina São José, Carla Pereira, Marta Ferreira, Ana André, Hugo Osório, Irene Gullo, Fátima Carneiro, Carla Oliveira
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Biology
Subjects:
gastric cancer
cadherins switch
regulatory elements
3D chromatin architecture
chromatin interactions
CDH1
Online Access:https://www.mdpi.com/2079-7737/12/6/803

Internet

https://www.mdpi.com/2079-7737/12/6/803

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