Rhenium N-heterocyclic carbene complexes block growth of aggressive cancers by inhibiting FGFR- and SRC-mediated signalling

Rhenium N-heterocyclic carbene complexes block growth of aggressive cancers by inhibiting FGFR- and SRC-mediated signalling

Abstract Background Platinum-based anticancer drugs have been at the frontline of cancer therapy for the last 40 years, and are used in more than half of all treatments for different cancer types. However, they are not universally effective, and patients often suffer severe side effects because of t...

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Bibliographic Details
Main Authors: Alice Domenichini, Ilaria Casari, Peter V. Simpson, Nima Maheshkumar Desai, Lingfeng Chen, Christopher Dustin, Jeanne S. Edmands, Albert van der Vliet, Moosa Mohammadi, Massimiliano Massi, Marco Falasca
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Rhenium complexes
Pancreatic cancer
Neuroblastoma
FGFR
Src
Online Access:https://doi.org/10.1186/s13046-020-01777-7

Internet

https://doi.org/10.1186/s13046-020-01777-7

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