Conversion of RpoS<sup>−</sup> Attenuated <named-content content-type="genus-species">Salmonella enterica</named-content> Serovar Typhi Vaccine Strains to RpoS<sup>+</sup> Improves Their Resistance to Host Defense Barriers
ABSTRACT The vast majority of live attenuated typhoid vaccines are constructed from the Salmonella enterica serovar Typhi strain Ty2, which is devoid of a functioning alternative sigma factor, RpoS, due to the presence of a frameshift mutation. RpoS is a specialized sigma factor that plays an import...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Society for Microbiology
2018-02-01
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| Series: | mSphere |
| Subjects: | |
| Online Access: | https://journals.asm.org/doi/10.1128/mSphere.00006-18 |