Synthesis and In Vitro Assessment of pH-Sensitive Human Serum Albumin Conjugates of Pirarubicin

Synthesis and In Vitro Assessment of pH-Sensitive Human Serum Albumin Conjugates of Pirarubicin

In a previous study, we reported on the development of a synthetic polymer conjugate of pirarubicin (THP) that was formed via an acid-labile hydrazone bond between the polymer and the THP. However, the synthetic polymer itself was non-biodegradable, which could lead to unexpected adverse effects. Hu...

Full description

Bibliographic Details
Main Authors: Kenji Tsukigawa, Shuhei Imoto, Keishi Yamasaki, Koji Nishi, Toshihiko Tsutsumi, Shoko Yokoyama, Yu Ishima, Masaki Otagiri
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Pharmaceuticals
Subjects:
pirarubicin (THP)
human serum albumin (HSA)
HSA-drug conjugates
pH-sensitive
drug release
cytotoxicity
Online Access:https://www.mdpi.com/1424-8247/14/1/22

Internet

https://www.mdpi.com/1424-8247/14/1/22

Similar Items