Mechanism and therapeutic potential of targeting cGAS-STING signaling in neurological disorders

Mechanism and therapeutic potential of targeting cGAS-STING signaling in neurological disorders

Abstract DNA sensing is a pivotal component of the innate immune system that is responsible for detecting mislocalized DNA and triggering downstream inflammatory pathways. Among the DNA sensors, cyclic GMP-AMP synthase (cGAS) is a primary player in detecting cytosolic DNA, including foreign DNA from...

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Bibliographic Details
Main Authors: Yige Huang, Bangyan Liu, Subhash C. Sinha, Sadaf Amin, Li Gan
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Molecular Neurodegeneration
Subjects:
cGAS
STING
Interferon response
Cytosolic dsDNA
Antiviral
Neuroinflammation
Online Access:https://doi.org/10.1186/s13024-023-00672-x

Internet

https://doi.org/10.1186/s13024-023-00672-x

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