Optimized Parameters for Transducing the Locus Coeruleus Using Canine Adenovirus Type 2 (CAV2) Vector in Rats for Chemogenetic Modulation Research

Optimized Parameters for Transducing the Locus Coeruleus Using Canine Adenovirus Type 2 (CAV2) Vector in Rats for Chemogenetic Modulation Research

IntroductionThe locus coeruleus noradrenergic (LC-NA) system is studied for its role in various neurological and psychiatric disorders such as epilepsy and Major Depression Dissorder. Chemogenetics is a powerful technique for specific manipulation of the LC to investigate its functioning. Local inje...

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Bibliographic Details
Main Authors: Latoya Stevens, Lars Emil Larsen, Wouter Van Lysebettens, Evelien Carrette, Paul Boon, Robrecht Raedt, Kristl Vonck
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Neuroscience
Subjects:
locus coeruleus
chemogenetics
designer receptor exclusively activated by designer drugs
canine associated viral vector
neurological disorder
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.663337/full

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https://www.frontiersin.org/articles/10.3389/fnins.2021.663337/full

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