Alpha1-antitrypsin protects the immature mouse brain following hypoxic-ischemic injury

Alpha1-antitrypsin protects the immature mouse brain following hypoxic-ischemic injury

Introduction: Preterm brain injury often leads to lifelong disabilities affecting both cognitive and motor functions, and effective therapies are limited. Alpha1-antitrypsin (AAT), an endogenous inhibitor of serine proteinases with anti-inflammatory, anti-apoptotic, and cytoprotective properties, mi...

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Bibliographic Details
Main Authors: Shan Zhang, Wendong Li, Yiran Xu, Tao Li, Joakim Ek, Xiaoli Zhang, Yafeng Wang, Juan Song, Changlian Zhu, Xiaoyang Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Cellular Neuroscience
Subjects:
alpha1-antitrypsin
neuroprotection
hypoxia-ischemia
neonatal brain injury
immature brain
motor dysfunction
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2023.1137497/full

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https://www.frontiersin.org/articles/10.3389/fncel.2023.1137497/full

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