Severe COVID-19-associated variants linked to chemokine receptor gene control in monocytes and macrophages

Severe COVID-19-associated variants linked to chemokine receptor gene control in monocytes and macrophages

Abstract Genome-wide association studies have identified 3p21.31 as the main risk locus for severe COVID-19, although underlying mechanisms remain elusive. We perform an epigenomic dissection of 3p21.31, identifying a CTCF-dependent tissue-specific 3D regulatory chromatin hub that controls the activ...

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Bibliographic Details
Main Authors: Bernard S. Stikker, Grégoire Stik, Antoinette F. van Ouwerkerk, Lianne Trap, Salvatore Spicuglia, Rudi W. Hendriks, Ralph Stadhouders
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Genome Biology
Subjects:
SARS-CoV-2
COVID-19
3p21.31
GWAS
Monocyte
Macrophage
Online Access:https://doi.org/10.1186/s13059-022-02669-z

Internet

https://doi.org/10.1186/s13059-022-02669-z

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