Comparison between intratumoral and intravenously administered oncolytic virus therapy with Newcastle disease virus in a xenograft murine model for pancreatic adenocarcinoma

Comparison between intratumoral and intravenously administered oncolytic virus therapy with Newcastle disease virus in a xenograft murine model for pancreatic adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a poor clinical prognosis and is usually a metastatic disease. In the last decades, oncolytic viro-immunotherapy has shown a promise as treatment strategy with encouraging results for a variety of tumors. Newcastle Disease Virus (NDV) is an...

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Bibliographic Details
Main Authors: J. Fréderique de Graaf, Marco Huberts, Daphne Groeneveld, Stefan van Nieuwkoop, Casper H.J. van Eijck, Ron A.M. Fouchier, Bernadette G. van den Hoogen
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Heliyon
Subjects:
Newcastle disease virus
Oncolytic viruses
Safety
Treatment efficacy
Intravenous administration
Intratumoral administration
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844022012038

Internet

http://www.sciencedirect.com/science/article/pii/S2405844022012038

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