Modification of RNF183 via m6A Methylation Mediates Podocyte Dysfunction in Diabetic Nephropathy by Regulating PKM2 Ubiquitination and Degradation

Modification of RNF183 via m6A Methylation Mediates Podocyte Dysfunction in Diabetic Nephropathy by Regulating PKM2 Ubiquitination and Degradation

Diabetic kidney disease (DKD) is a prevalent complication associated with diabetes in which podocyte dysfunction significantly contributes to the development and progression of the condition. Ring finger protein 183 (RNF183) is an ER-localized, transmembrane ring finger protein with classical E3 lig...

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Bibliographic Details
Main Authors: Dongwei Guo, Yingxue Pang, Wenjie Wang, Yueying Feng, Luxuan Wang, Yuanyuan Sun, Jun Hao, Fan Li, Song Zhao
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Cells
Subjects:
diabetic kidney disease
RNF183
m6A methylation
ubiquitination
PKM2
Online Access:https://www.mdpi.com/2073-4409/14/5/365

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https://www.mdpi.com/2073-4409/14/5/365

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