Transient, Consequential Increases in Extracellular Potassium Ions Accompany Channelrhodopsin2 Excitation

Transient, Consequential Increases in Extracellular Potassium Ions Accompany Channelrhodopsin2 Excitation

Summary: Channelrhodopsin2 (ChR2) optogenetic excitation is widely used to study neurons, astrocytes, and circuits. Using complementary approaches in situ and in vivo, we found that ChR2 stimulation leads to significant transient elevation of extracellular potassium ions by ∼5 mM. Such elevations we...

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Bibliographic Details
Main Authors: J. Christopher Octeau, Mohitkumar R. Gangwani, Sushmita L. Allam, Duy Tran, Shuhan Huang, Tuan M. Hoang-Trong, Peyman Golshani, Timothy H. Rumbell, James R. Kozloski, Baljit S. Khakh
Format: Article
Language:English
Published: Elsevier 2019-05-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719305583

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http://www.sciencedirect.com/science/article/pii/S2211124719305583

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