Anticancer mechanism of 7-α-hydroxyfrullanolide on microtubules and computational prediction of its target binding in triple-negative breast cancer cells

Anticancer mechanism of 7-α-hydroxyfrullanolide on microtubules and computational prediction of its target binding in triple-negative breast cancer cells

Background Triple-negative breast cancer (TNBC) responds poorly to the available drugs; thus, the mortality rate associated with TNBC remains high. 7-α-Hydroxyfrullanolide (7HF) possesses anticancer properties and arrests cells in the G2/M-phase via modulation of several proteins involved in the G2/...

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Bibliographic Details
Main Authors: Siriphorn Chimplee, Carl Smythe, Varomyalin Tipmanee, Suchada Sukrong, Kanyanatt Kanokwiroon
Format: Article
Language:English
Published: PeerJ Inc. 2022-05-01
Series:PeerJ
Subjects:
7-α-Hydroxyfrullanolide
Sesquiterpene lactones
Natural product
Triple-negative breast cancer
Microtubules
G2/M arrest
Online Access:https://peerj.com/articles/13508.pdf

Internet

https://peerj.com/articles/13508.pdf

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