Genome-wide screening in pluripotent cells identifies Mtf1 as a suppressor of mutant huntingtin toxicity

Genome-wide screening in pluripotent cells identifies Mtf1 as a suppressor of mutant huntingtin toxicity

Abstract Huntington’s disease (HD) is a neurodegenerative disorder caused by CAG-repeat expansions in the huntingtin (HTT) gene. The resulting mutant HTT (mHTT) protein induces toxicity and cell death via multiple mechanisms and no effective therapy is available. Here, we employ a genome-wide screen...

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Bibliographic Details
Main Authors: Giorgia Maria Ferlazzo, Anna Maria Gambetta, Sonia Amato, Noemi Cannizzaro, Silvia Angiolillo, Mattia Arboit, Linda Diamante, Elena Carbognin, Patrizia Romani, Federico La Torre, Elena Galimberti, Florian Pflug, Mirko Luoni, Serena Giannelli, Giuseppe Pepe, Luca Capocci, Alba Di Pardo, Paola Vanzani, Lucio Zennaro, Vania Broccoli, Martin Leeb, Enrico Moro, Vittorio Maglione, Graziano Martello
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-39552-9

Internet

https://doi.org/10.1038/s41467-023-39552-9

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