A LRRK2 GTP Binding Inhibitor, 68, Reduces LPS-Induced Signaling Events and TNF-α Release in Human Lymphoblasts

A LRRK2 GTP Binding Inhibitor, 68, Reduces LPS-Induced Signaling Events and TNF-α Release in Human Lymphoblasts

Mutations in <i>the leucine-rich repeat kinase-2 (LRRK2)</i> gene cause autosomal-dominant Parkinson’s disease (PD) and contribute to sporadic PD. Common genetic variation in LRRK2 modifies susceptibility to immunological disorders including Crohn’s disease and leprosy. Previous studies...

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Bibliographic Details
Main Authors: Tianxia Li, Bo Ning, Lingbo Kong, Bingling Dai, Xiaofei He, Joseph M. Thomas, Akira Sawa, Christopher A. Ross, Wanli W. Smith
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cells
Subjects:
LRRK2
GTP binding inhibitor
LPS
TNF-α
lymphoblast
Parkinson’s disease
Online Access:https://www.mdpi.com/2073-4409/10/2/480

Internet

https://www.mdpi.com/2073-4409/10/2/480

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