An Ultrahigh‐Density Microneedle Array for Skin Vaccination: Inducing Epidermal Cell Death by Increasing Microneedle Density Enhances Total IgG and IgG1 Immune Responses

An Ultrahigh‐Density Microneedle Array for Skin Vaccination: Inducing Epidermal Cell Death by Increasing Microneedle Density Enhances Total IgG and IgG1 Immune Responses

Many types of microneedle (MN) arrays have been tested for delivery of vaccines to the skin. However, the effect of MN geometry/array design on antibody production is still unclear. Reports suggest that systemic immune responses may be affected by how MN arrays “mechanically” deliver vaccines, which...

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Bibliographic Details
Main Authors: Jacob W. Coffey, Nicole M. D. van der Burg, Thippayawan Rananakomol, Hwee-Ing Ng, Germain J. P. Fernando, Mark A. F. Kendall
Format: Article
Language:English
Published: Wiley-VCH 2022-08-01
Series:Advanced NanoBiomed Research
Subjects:
adjuvant
antibody IgG
cell death
density
microneedles
skin vaccination
Online Access:https://doi.org/10.1002/anbr.202100151

Internet

https://doi.org/10.1002/anbr.202100151

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