Metabolic engineering of Streptomyces to enhance the synthesis of valuable natural products

The mycelial bacterium Streptomyces is a workhorse for producing natural products, serving as a key source of drugs and other valuable chemicals. However, its complicated life cycle, silent biosynthetic gene clusters (BGCs), and poorly characterized metabolic mechanisms limit efficient production of...

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Bibliographic Details
Main Authors: Zuwei Xu, Lihao Ji, Wenxiu Tang, Liang Guo, Cong Gao, Xiulai Chen, Jia Liu, Guipeng Hu, Liming Liu
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Engineering Microbiology
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2667370322000133