Metabolic engineering of Streptomyces to enhance the synthesis of valuable natural products
The mycelial bacterium Streptomyces is a workhorse for producing natural products, serving as a key source of drugs and other valuable chemicals. However, its complicated life cycle, silent biosynthetic gene clusters (BGCs), and poorly characterized metabolic mechanisms limit efficient production of...
Main Authors: | Zuwei Xu, Lihao Ji, Wenxiu Tang, Liang Guo, Cong Gao, Xiulai Chen, Jia Liu, Guipeng Hu, Liming Liu |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2022-06-01
|
Series: | Engineering Microbiology |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2667370322000133 |
Similar Items
-
Improvement of pristinamycin I (PI) production in Streptomyces pristinaespiralis by metabolic engineering approaches
by: Jiali Meng, et al.
Published: (2017-06-01) -
The roles of SARP family regulators involved in secondary metabolism in Streptomyces
by: Yusi Yan, et al.
Published: (2024-03-01) -
Diverse and Abundant Secondary Metabolism Biosynthetic Gene Clusters in the Genomes of Marine Sponge Derived Streptomyces spp. Isolates
by: Stephen A. Jackson, et al.
Published: (2018-02-01) -
Genetic interrelations in the actinomycin biosynthetic gene clusters of Streptomyces antibioticus IMRU 3720 and Streptomyces chrysomallus ATCC11523, producers of actinomycin X and actinomycin C
by: Crnovčić I, et al.
Published: (2017-04-01) -
Mining the Biosynthetic Potential for Specialized Metabolism of a <i>Streptomyces</i> Soil Community
by: Matthieu Nicault, et al.
Published: (2020-05-01)