Structure of the CLC-1 chloride channel from Homo sapiens

CLC channels mediate passive Cl− conduction, while CLC transporters mediate active Cl− transport coupled to H+ transport in the opposite direction. The distinction between CLC-0/1/2 channels and CLC transporters seems undetectable by amino acid sequence. To understand why they are different function...

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Detalhes bibliográficos
Main Authors: Eunyong Park, Roderick MacKinnon
Formato: Artigo
Idioma:English
Publicado em: eLife Sciences Publications Ltd 2018-05-01
Colecção:eLife
Assuntos:
Acesso em linha:https://elifesciences.org/articles/36629