Glycosylated Ang-(1-7) MasR Agonist Peptide Poly Lactic-co-Glycolic Acid (PLGA) Nanoparticles and Microparticles in Cognitive Impairment: Design, Particle Preparation, Physicochemical Characterization, and In Vitro Release

Glycosylated Ang-(1-7) MasR Agonist Peptide Poly Lactic-co-Glycolic Acid (PLGA) Nanoparticles and Microparticles in Cognitive Impairment: Design, Particle Preparation, Physicochemical Characterization, and In Vitro Release

Heart failure (HF) causes decreased brain perfusion in older adults, and increased brain and systemic inflammation increases the risk of cognitive impairment and Alzheimer’s disease (AD). Glycosylated Ang-(1-7) MasR agonists (PNA5) has shown improved bioavailability, stability, and brain penetration...

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Bibliographic Details
Main Authors: David Encinas-Basurto, John P. Konhilas, Robin Polt, Meredith Hay, Heidi M. Mansour
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Pharmaceutics
Subjects:
PNA5 glycopeptide
mas receptor
angiotensin
PLGA diblock copolymer
ester and acid-end capped
double emulsion solvent evaporation
Online Access:https://www.mdpi.com/1999-4923/14/3/587

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https://www.mdpi.com/1999-4923/14/3/587

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