The Putative Endonuclease Activity of MutL Is Required for the Segmental Gene Conversion Events That Drive Antigenic Variation of the Lyme Disease Spirochete

The Putative Endonuclease Activity of MutL Is Required for the Segmental Gene Conversion Events That Drive Antigenic Variation of the Lyme Disease Spirochete

The Lyme disease spirochete Borrelia burgdorferi, encodes an elaborate antigenic variation system that promotes the ongoing variation of a major surface lipoprotein, VlsE. Changes in VlsE are continual and always one step ahead of the host acquired immune system, which requires 1–2 weeks to generate...

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Bibliographic Details
Main Authors: Mildred Castellanos, Theodore B. Verhey, Madeleine Goldstein, George Chaconas
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Microbiology
Subjects:
Lyme disease
borreliosis
Borrelia
antigenic variation
vlsE
gene conversion
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.888494/full

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https://www.frontiersin.org/articles/10.3389/fmicb.2022.888494/full

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