Missense variants in SORT1 are associated with LDL-C in an Amish population

Missense variants in SORT1 are associated with LDL-C in an Amish population

Common noncoding variants at the human 1p13.3 locus associated with SORT1 expression are among those most strongly associated with low-density lipoprotein cholesterol (LDL-C) in human genome-wide association studies. However, validation studies in mice and cell lines have produced variable results r...

Full description

Bibliographic Details
Main Authors: Kelly A. Mitok, Kathryn L. Schueler, Sarah M. King, Joseph Orr, Kathleen A. Ryan, Mark P. Keller, Ronald M. Krauss, Braxton D. Mitchell, Alan R. Shuldiner, Alan D. Attie
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Journal of Lipid Research
Subjects:
cholesterol/metabolism
dyslipidemias
LDL/metabolism
lipoproteins/metabolism
lipoproteins/receptors
genetic association
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227523001414

Internet

http://www.sciencedirect.com/science/article/pii/S0022227523001414

Similar Items