Characterization of winged helix domain fusion endonucleases as N6-methyladenine-dependent type IV restriction systems

Characterization of winged helix domain fusion endonucleases as N6-methyladenine-dependent type IV restriction systems

Winged helix (wH) domains, also termed winged helix-turn-helix (wHTH) domains, are widespread in all kingdoms of life and have diverse roles. In the context of DNA binding and DNA modification sensing, some eukaryotic wH domains are known as sensors of non-methylated CpG. In contrast, the prokaryoti...

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Bibliographic Details
Main Authors: Igor Helbrecht, Daniel Heiter, Weiwei Yang, Tamas Vincze, Andrew Hanneman, Thomas Lutz, Laurence Ettwiller, Matthias Bochtler, Shuang-yong Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Microbiology
Subjects:
winged helix fusion endonucleases
HNH endonuclease
GIY-YIG endonuclease
PLD family endonuclease
N6mA-dependent restriction system
genome conflict
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2024.1286822/full

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https://www.frontiersin.org/articles/10.3389/fmicb.2024.1286822/full

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