Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-ΙΙ

Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-ΙΙ

Abstract Background Pyroptosis is a lytic cell death form executed by gasdermins family proteins. Induction of tumor pyroptosis promotes anti-tumor immunity and is a potential cancer treatment strategy. Triptolide (TPL) is a natural product isolated from the traditional Chinese herb which possesses...

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Bibliographic Details
Main Authors: Jing Cai, Mei Yi, Yixin Tan, Xiaoling Li, Guiyuan Li, Zhaoyang Zeng, Wei Xiong, Bo Xiang
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Head and neck squamous cell carcinoma
Ferroptosis
Gasdermins
Nasopharyngeal carcinoma
X(c)(−) cysteine/glutamate antiporter
Online Access:https://doi.org/10.1186/s13046-021-01995-7

Internet

https://doi.org/10.1186/s13046-021-01995-7

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