Role of the NaHCO3 Transporter MpsABC in the NaHCO3–β-Lactam-Responsive Phenotype in Methicillin-Resistant Staphylococcus aureus

Role of the NaHCO3 Transporter MpsABC in the NaHCO3–β-Lactam-Responsive Phenotype in Methicillin-Resistant Staphylococcus aureus

ABSTRACT Methicillin-resistant Staphylococcus aureus (MRSA) infections are an increasing concern due to their intrinsic resistance to most standard-of-care β-lactam antibiotics. Recent studies of clinical isolates have documented a novel phenotype, termed NaHCO3 responsiveness, in which a substantia...

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Bibliographic Details
Main Authors: Sook-Ha Fan, Richard A. Proctor, Selvi C. Ersoy, Adhar C. Manna, Ambrose L. Cheung, Friedrich Götz, Henry F. Chambers, Arnold S. Bayer
Format: Article
Language:English
Published: American Society for Microbiology 2023-06-01
Series:Microbiology Spectrum
Subjects:
methicillin-resistant Staphylococcus aureus
MRSA
sodium bicarbonate
CO2
β-lactams
bicarbonate transporter
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00141-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.00141-23

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