Development of Highly Selective Kv1.3-Blocking Peptides Based on the Sea Anemone Peptide ShK

Development of Highly Selective Kv1.3-Blocking Peptides Based on the Sea Anemone Peptide ShK

ShK, from the sea anemone Stichodactyla helianthus, is a 35-residue disulfide-rich peptide that blocks the voltage-gated potassium channel Kv1.3 at ca. 10 pM and the related channel Kv1.1 at ca. 16 pM. We developed an analog of this peptide, ShK-186, which is currently in Phase 1b-2a clinical tria...

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Bibliographic Details
Main Authors: Michael W. Pennington, Shih Chieh Chang, Satendra Chauhan, Redwan Huq, Rajeev B. Tajhya, Sandeep Chhabra, Raymond S. Norton, Christine Beeton
Format: Article
Language:English
Published: MDPI AG 2015-01-01
Series:Marine Drugs
Subjects:
immunomodulator
T lymphocyte
potassium channel
disulfide-rich peptide
sea anemone toxin
K+ channel blocker
Online Access:http://www.mdpi.com/1660-3397/13/1/529

Internet

http://www.mdpi.com/1660-3397/13/1/529

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