The Coumarin-Derivative Esculetin Protects against Lipotoxicity in Primary Rat Hepatocytes via Attenuating JNK-Mediated Oxidative Stress and Attenuates Free Fatty Acid-Induced Lipid Accumulation

Coumarin derivates have been proposed as a potential treatment for metabolic-dysfunction-associated fatty liver disease (MAFLD). However, the mechanisms underlying their beneficial effects remain unclear. In the present study, we explored the potential of the coumarin derivate esculetin in MAFLD, fo...

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Bibliographic Details
Main Authors: Mengmeng Xia, Zongmei Wu, Junyu Wang, Manon Buist-Homan, Han Moshage
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Antioxidants
Subjects:
Online Access:https://www.mdpi.com/2076-3921/12/11/1922