SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target

SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target

Viruses rely on host cell metabolism for replication, making these pathways potential therapeutic targets. Here, the authors show that AM580, a retinoid derivative and RAR-α agonist, affects replication of several RNA viruses by interfering with the activity of SREBP.

Bibliographic Details
Main Authors: Shuofeng Yuan, Hin Chu, Jasper Fuk-Woo Chan, Zi-Wei Ye, Lei Wen, Bingpeng Yan, Pok-Man Lai, Kah-Meng Tee, Jingjing Huang, Dongdong Chen, Cun Li, Xiaoyu Zhao, Dong Yang, Man Chun Chiu, Cyril Yip, Vincent Kwok-Man Poon, Chris Chung-Sing Chan, Kong-Hung Sze, Jie Zhou, Ivy Hau-Yee Chan, Kin-Hang Kok, Kelvin Kai-Wang To, Richard Yi-Tsun Kao, Johnson Yiu-Nam Lau, Dong-Yan Jin, Stanley Perlman, Kwok-Yung Yuen
Format: Article
Language:English
Published: Nature Portfolio 2019-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-08015-x

Internet

https://doi.org/10.1038/s41467-018-08015-x

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