Oxidative stress gene expression, DNA methylation, and gut microbiota interaction trigger Crohn’s disease: a multi-omics Mendelian randomization study

Oxidative stress gene expression, DNA methylation, and gut microbiota interaction trigger Crohn’s disease: a multi-omics Mendelian randomization study

Abstract Background Oxidative stress (OS) is a key pathophysiological mechanism in Crohn’s disease (CD). OS-related genes can be affected by environmental factors, intestinal inflammation, gut microbiota, and epigenetic changes. However, the role of OS as a potential CD etiological factor or trigger...

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Bibliographic Details
Main Authors: Shu Xu, Xiaozhi Li, Shenghong Zhang, Cancan Qi, Zhenhua Zhang, Ruiqi Ma, Liyuan Xiang, Lianmin Chen, Yijun Zhu, Ce Tang, Arno R. Bourgonje, Miaoxin Li, Yao He, Zhirong Zeng, Shixian Hu, Rui Feng, Minhu Chen
Format: Article
Language:English
Published: BMC 2023-05-01
Series:BMC Medicine
Subjects:
Oxidative stress
Crohn’s disease
Integrative omics
Mendelian randomization
Online Access:https://doi.org/10.1186/s12916-023-02878-8

Internet

https://doi.org/10.1186/s12916-023-02878-8

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