Radiosensitization effect by HDAC inhibition improves NKG2D-dependent natural killer cytotoxicity in hepatocellular carcinoma

Radiosensitization effect by HDAC inhibition improves NKG2D-dependent natural killer cytotoxicity in hepatocellular carcinoma

BackgroundHepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide. Radiotherapy (RT) controls HCC unsatisfactorily and temporarily. Histone deacetylase inhibitor (HDACi) is a heterogeneous group of epigenetic therapeutics with promising anticancer effects and sy...

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Bibliographic Details
Main Authors: Yu-Fan Liu, Yun Chiang, Feng-Ming Hsu, Chiao-Ling Tsai, Jason Chia-Hsien Cheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Oncology
Subjects:
hepatocellular carcinoma
radiotherapy
histone deacetylase inhibition
NKG2D ligand
NK cell-mediated cytotoxicity
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1009089/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.1009089/full

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