Suppression of endothelial ceramide de novo biosynthesis by Nogo-B contributes to cardiometabolic diseases

Suppression of endothelial ceramide de novo biosynthesis by Nogo-B contributes to cardiometabolic diseases

Abstract Accrual of ceramides, membrane and bioactive sphingolipids, has been implicated in endothelial dysfunction preceding cardiometabolic diseases. Yet, direct in vivo evidence, underlying mechanisms, and pathological implications are lacking. Here we show that suppression of ceramides and sphin...

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Bibliographic Details
Main Authors: Luisa Rubinelli, Onorina Laura Manzo, Jin Sungho, Ilaria Del Gaudio, Rohan Bareja, Alice Marino, Sailesh Palikhe, Vittoria Di Mauro, Mariarosaria Bucci, Domenick J. Falcone, Olivier Elemento, Baran Ersoy, Sabrina Diano, Linda Sasset, Annarita Di Lorenzo
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56869-9

Internet

https://doi.org/10.1038/s41467-025-56869-9

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