Myeloid-specific blockade of notch signaling alleviates dopaminergic neurodegeneration in Parkinson’s disease by dominantly regulating resident microglia activation through NF-κB signaling

Myeloid-specific blockade of notch signaling alleviates dopaminergic neurodegeneration in Parkinson’s disease by dominantly regulating resident microglia activation through NF-κB signaling

Yolk sac–derived microglia and peripheral monocyte–derived macrophages play a key role during Parkinson’s disease (PD) progression. However, the regulatory mechanism of microglia/macrophage activation and function in PD pathogenesis remains unclear. Recombination signal–binding protein Jκ (RBP-J)–me...

Full description

Bibliographic Details
Main Authors: Shi-Qian Liang, Peng-Hui Li, Yi-Yang Hu, Jun-Long Zhao, Fang-Ze Shao, Fang Kuang, Kai-Xi Ren, Tiao-Xia Wei, Fan Fan, Lei Feng, Hua Han, Hong-Yan Qin
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Immunology
Subjects:
notch signaling
Parkinson’s disease
microglia
monocyte-derived macrophages
neuroinflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1193081/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1193081/full

Similar Items