Nucleotide-level linkage of transcriptional elongation and polyadenylation

Nucleotide-level linkage of transcriptional elongation and polyadenylation

Alternative polyadenylation yields many mRNA isoforms whose 3’ termini occur disproportionately in clusters within 3’ untranslated regions. Previously, we showed that profiles of poly(A) site usage are regulated by the rate of transcriptional elongation by RNA polymerase (Pol) II (Geisberg et al., 2...

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Bibliographic Details
Main Authors: Joseph V Geisberg, Zarmik Moqtaderi, Nova Fong, Benjamin Erickson, David L Bentley, Kevin Struhl
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-11-01
Series:eLife
Subjects:
3' end formation
polyadenylation
RNA polymerase II
transcriptional elongation
cleavage/polyadenylation machinery
Online Access:https://elifesciences.org/articles/83153

Internet

https://elifesciences.org/articles/83153

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