Time‐series transcriptomics and proteomics reveal alternative modes to decode p53 oscillations

Abstract The cell stress‐responsive transcription factor p53 influences the expression of its target genes and subsequent cellular responses based in part on its dynamics (changes in level over time). The mechanisms decoding p53 dynamics into subsequent target mRNA and protein dynamics remain unclea...

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Bibliographic Details
Main Authors: Alba Jiménez, Dan Lu, Marian Kalocsay, Matthew J Berberich, Petra Balbi, Ashwini Jambhekar, Galit Lahav
Format: Article
Language:English
Published: Springer Nature 2022-03-01
Series:Molecular Systems Biology
Subjects:
Online Access:https://doi.org/10.15252/msb.202110588