Inhibition of ChREBP ubiquitination via the ROS/Akt-dependent downregulation of Smurf2 contributes to lysophosphatidic acid-induced fibrosis in renal mesangial cells

Inhibition of ChREBP ubiquitination via the ROS/Akt-dependent downregulation of Smurf2 contributes to lysophosphatidic acid-induced fibrosis in renal mesangial cells

Abstract Background Mesangial cell fibrosis, a typical symptom of diabetic nephropathy (DN), is a major contributor to glomerulosclerosis. We previously reported that the pharmacological blockade of lysophosphatidic acid (LPA) signaling improves DN. Although LPA signaling is implicated in diabetic r...

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Bibliographic Details
Main Authors: Donghee Kim, Ga-Young Nam, Eunhui Seo, Hee-Sook Jun
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Journal of Biomedical Science
Subjects:
Diabetic nephropathy
Mesangial cells
Fibrosis
Lysophosphatidic acid
ChREBP
Smurf2
Online Access:https://doi.org/10.1186/s12929-022-00814-1

Internet

https://doi.org/10.1186/s12929-022-00814-1

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