Divergent Molecular and Cellular Responses to Low and High-Dose Ionizing Radiation

Divergent Molecular and Cellular Responses to Low and High-Dose Ionizing Radiation

Cancer risk after ionizing radiation (IR) is assumed to be linear with the dose; however, for low doses, definite evidence is lacking. Here, using temporal multi-omic systems analyses after a low (LD; 0.1 Gy) or a high (HD; 1 Gy) dose of X-rays, we show that, although the DNA damage response (DDR) d...

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Bibliographic Details
Main Authors: Bharath Sampadi, Sylvia Vermeulen, Branislav Mišovic, Jan J. Boei, Tanveer S. Batth, Jer-Gung Chang, Michelle T. Paulsen, Brian Magnuson, Joost Schimmel, Hanneke Kool, Cyriel S. Olie, Bart Everts, Alfred C. O. Vertegaal, Jesper V. Olsen, Mats Ljungman, Penny A. Jeggo, Leon H. F. Mullenders, Harry Vrieling
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Cells
Subjects:
ionizing radiation
low dose
linear no-threshold
signal transduction
cell signaling
DNA damage response
Online Access:https://www.mdpi.com/2073-4409/11/23/3794

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https://www.mdpi.com/2073-4409/11/23/3794

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